Additional file 6: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
- Simon Heine (5718920)
- Markus Kleih (5718926)
- Neus Giménez (5718941)
- Kathrin Böpple (4332913)
- German Ott (216544)
- Dolors Colomer (1593736)
- Walter Aulitzky (5718935)
- Heiko van der Kuip (52857)
- Elisabeth Silkenstedt (5718938)
Publication date
September 2018
DOIAbstract
Figure S5. Inhibition CDK4 activity hardly alters NOXA mRNA levels after proteasome inhibition. MCL cell line Mino was treated with 100 nM and Granta-519 with 300 nM Palbociclib for 16 h and subsequently co-treated with 8 nM bortezomib. After 8 h co-treatment samples were taken and analyzed by real-time PCR. NOXA mRNA expression was normalized to TBP. Data represent means ± SD from three experiments. (TIFF 569 kb
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