Additional file 2: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Additional file 14: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S13. NOXA protein contains a potential LIR motif. The amino acid sequence DGFRRL at the posit...

Additional file 1: of Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

Dandan Li (391591)
John Mullinax (5142680)
Taylor Aiken (3359006)
Hongwu Xin (5576879)
Gordon Wiegand (5576882)
Andrew Anderson (2037469)
Snorri Thorgeirsson (5576885)
Itzhak Avital (5576888)
Udo Rudloff (2560027)

July 2018

Figure S1. Confirmation of silencing of BMX, NRTK2, and PDPK1 mediated by siRNA (set 1- #1) knockdow...

Additional file 1: of BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Ganlu Deng (3464573)
Shan Zeng (3464564)
Yanling Qu (5519885)
Qingqing Luo (5519894)
Cao Guo (3464567)
Ling Yin (416656)
Ying Han (137520)
Yiyi Li (1968925)
Changjing Cai (5519888)
Yaojie Fu (5519891)
Hong Shen (166278)

July 2018

Figure S1. Original blots of Western blot. Original blots of Fig. 1. (2) Original blots of Fig. 2. (...

Additional file 8: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S7. Palbociclib treatment induces autophagy but not after a short treatment period. (A) MCL c...

Additional file 9: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S8. Autophagy inhibitors counteract palbociclib-mediated antagonism on bortezomib-induced cel...

Additional file 7: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S6. Palbociclib-mediated antagonism on bortezomib-induced cell death is not caused by alterat...

Additional file 6: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S5. Inhibition CDK4 activity hardly alters NOXA mRNA levels after proteasome inhibition. MCL ...

Additional file 5: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S4. CDK4 inhibition antagonizes cell death of NOXA inducing substances. MCL cell line Jeko-1 ...

Additional file 3: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S2. Knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death. MCL cell line ...

Additional file 12: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S11. Combination of proteasome inhibition and simultaneous fatty acid inhibition regulates ma...

Additional file 4: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S3. Double knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death similar ...

Additional file 10: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S9. Co-treatment of bortezomib with autophagy inhibitors potentiates cell death induction. MC...

Additional file 1: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Table S1. Sequences targeted by the siRNAs used for gene silencing. (TIFF 883 kb

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death....

Additional file 14: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S13. NOXA protein contains a potential LIR motif. The amino acid sequence DGFRRL at the posit...

Additional file 1: of Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

Dandan Li (391591)
John Mullinax (5142680)
Taylor Aiken (3359006)
Hongwu Xin (5576879)
Gordon Wiegand (5576882)
Andrew Anderson (2037469)
Snorri Thorgeirsson (5576885)
Itzhak Avital (5576888)
Udo Rudloff (2560027)

July 2018

Figure S1. Confirmation of silencing of BMX, NRTK2, and PDPK1 mediated by siRNA (set 1- #1) knockdow...

Additional file 1: of BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Ganlu Deng (3464573)
Shan Zeng (3464564)
Yanling Qu (5519885)
Qingqing Luo (5519894)
Cao Guo (3464567)
Ling Yin (416656)
Ying Han (137520)
Yiyi Li (1968925)
Changjing Cai (5519888)
Yaojie Fu (5519891)
Hong Shen (166278)

July 2018

Figure S1. Original blots of Western blot. Original blots of Fig. 1. (2) Original blots of Fig. 2. (...

Additional file 8: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S7. Palbociclib treatment induces autophagy but not after a short treatment period. (A) MCL c...

Additional file 9: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S8. Autophagy inhibitors counteract palbociclib-mediated antagonism on bortezomib-induced cel...

Additional file 7: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S6. Palbociclib-mediated antagonism on bortezomib-induced cell death is not caused by alterat...

Additional file 6: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S5. Inhibition CDK4 activity hardly alters NOXA mRNA levels after proteasome inhibition. MCL ...

Additional file 5: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S4. CDK4 inhibition antagonizes cell death of NOXA inducing substances. MCL cell line Jeko-1 ...

Additional file 3: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S2. Knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death. MCL cell line ...

Additional file 12: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S11. Combination of proteasome inhibition and simultaneous fatty acid inhibition regulates ma...

Additional file 4: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S3. Double knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death similar ...

Additional file 10: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S9. Co-treatment of bortezomib with autophagy inhibitors potentiates cell death induction. MC...

Additional file 1: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Table S1. Sequences targeted by the siRNAs used for gene silencing. (TIFF 883 kb

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death....

Additional file 14: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S13. NOXA protein contains a potential LIR motif. The amino acid sequence DGFRRL at the posit...

Additional file 1: of Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

Dandan Li (391591)
John Mullinax (5142680)
Taylor Aiken (3359006)
Hongwu Xin (5576879)
Gordon Wiegand (5576882)
Andrew Anderson (2037469)
Snorri Thorgeirsson (5576885)
Itzhak Avital (5576888)
Udo Rudloff (2560027)

July 2018

Figure S1. Confirmation of silencing of BMX, NRTK2, and PDPK1 mediated by siRNA (set 1- #1) knockdow...

Additional file 1: of BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Ganlu Deng (3464573)
Shan Zeng (3464564)
Yanling Qu (5519885)
Qingqing Luo (5519894)
Cao Guo (3464567)
Ling Yin (416656)
Ying Han (137520)
Yiyi Li (1968925)
Changjing Cai (5519888)
Yaojie Fu (5519891)
Hong Shen (166278)

July 2018

Figure S1. Original blots of Western blot. Original blots of Fig. 1. (2) Original blots of Fig. 2. (...

Additional file 2: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Abstract

Extracted data

Additional file 2: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Abstract

Extracted data

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