Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death. MCL cell line Jeko-1 was treated with either five concentrations of carfilzomib or four concentrations of bortezomib and co-treated with four concentrations of orlistat (concentrations in the table). After 24Â h, cell death was assessed by AnnexinV-PI staining. Induced cell death was used as fractional effect for determining the combination index (CI). (TIFF 1773 kb