Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibition is caspase dependent. MCL cell line Jeko-1 was treated with 50 μM of the pan-caspase inhibitor Z-VAD-FMK for 2 h subsequently treated with 7 nM bortezomib or carfilzomib and co-treated with 15 μM orlistat. After 24 h, cell death was assessed by AnnexinV-PI staining. Data represent means ± S.D. from three experiments. (TIFF 774 kb