Additional file 10: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
- Simon Heine (5718920)
- Markus Kleih (5718926)
- Neus Giménez (5718941)
- Kathrin Böpple (4332913)
- German Ott (216544)
- Dolors Colomer (1593736)
- Walter Aulitzky (5718935)
- Heiko van der Kuip (52857)
- Elisabeth Silkenstedt (5718938)
Publication date
September 2018
DOIAbstract
Figure S9. Co-treatment of bortezomib with autophagy inhibitors potentiates cell death induction. MCL cell line Rec-1 was pretreated with 20 μM liensinine, 120 μM hydroxychloroquine, or 5 mM 3-MA for 16 h and subsequently co-treated with 8 nM bortezomib. After 24 h treatment, cell death was assessed by AnnexinV-PI staining. Data represent means ± S.D. from three independent experiments. (TIFF 725 kb
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