Additional file 12: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
- Simon Heine (5718920)
- Markus Kleih (5718926)
- Neus Giménez (5718941)
- Kathrin Böpple (4332913)
- German Ott (216544)
- Dolors Colomer (1593736)
- Walter Aulitzky (5718935)
- Heiko van der Kuip (52857)
- Elisabeth Silkenstedt (5718938)
Publication date
September 2018
DOIAbstract
Figure S11. Combination of proteasome inhibition and simultaneous fatty acid inhibition regulates mainly NOXA protein levels and not PUMA, BAX, BAK, or MCL1. MCL cell line Jeko-1 was treated with 7 nM bortezomib or carfilzomib and co-treated with 15 μM orlistat. After 14 h, protein expression was analyzed by Western blot. (TIFF 1502 kb
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