THS exposure results in hyperglycemia and decrease in insulin sensitivity.

<p>(<b>A</b>) Fasting glucose levels of mice exposed to THS were significantly increased in comparison to control. (<b>B</b>) Intraperitoneal Insulin Tolerance Test (IITT) time course and calculated area under the curve reveal that THS-exposed mice have decreased sensitivity to insulin which is highly correlated with both fatty liver disease and smoke exposure. (<b>C</b>) Intraperitoneal Glucose Tolerance Test (IGTT) time course shows impaired glucose clearance following glucose administration. *p<0.05, ** p<0.01, *** p<0.001.