Glucose intolerance and impaired glucose-induced insulin secretion in S2814D mice.

<p>(<b>A, B</b>) Glucose tolerance tests were conducted by injecting glucose (2 g/kg body weight) in WT and S2814D mice after a period of fasting for 6 hours. Quantifaction revealed glucose intolerance in S2814D mice as evidenced by higher blood glucose levels (<b>A</b>) and the lack of an insulin response (<b>B</b>). (<b>C</b>) Insulin tolerance tests were conducted by injecting insulin (0.75 U/kg body weight) after 6 h of fasting. (<b>D</b>) Acute phase insulin secretion in response to glucose (3 g/kg body weight) after 16 hours of fasting revealed a blunted response in S2814D mice. Data are represented as average ± SEM. N = 4−14 mice per group. **<i>P</i><0.01, *<i>P</i><0.05 vs. WT.