Impaired insulin and glucose tolerance IPGTT in WT and G4+/− mice exposed to HF IU/L.

<p>(A) ITT, following a 6 hr fast blood glucose levels were assessed at the indicated times following an i.p. injection of 0.75 U/kg insulin. Values are represented as the percent of t = 0 glucose levels, *p<0.05 G4+/− HF IU/L vs. WT HF IU/L; #p<0.02 G4+/−HF IU/L vs. G4 C IU/L; $p<0.05 WT HF IU/L vs. WT C IU/L. (B) GTT was performed following an overnight fast, mice were i.p. injected with 1.5 g/kg glucose and blood glucose levels determined at the indicated times, n = 5 per group. Values are represented as the percent of t = 0 glucose levels, #p<0.05 G4+/−HF IU/L vs. G4+/− C IU/L; $p<0.05 WT HF IU/L vs. WT C IU/L.