Glucose tolerance is mildly impaired and insulin sensitivity is similar between WT and T1R3 KO mice.

<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 23 weeks. Time course following glucose injection (left panel) and AUC (right panel). C) Serum insulin 30 min following glucose injection during IP GTT. D) Intraperitoneal insulin tolerance test (left panel) in WT (n = 6) and T1R3 KO (n = 8) mice on Western diet for 23.5 weeks. Quantification of AUC (right panel). E) Random fed glucose from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 24 weeks. F. Random fed NEFA from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 24 weeks. G. Serum NEFA from WT (n = 6) and T1R3 KO (n = 9) mice on Western Diet for 23 weeks, fasted for 16 h. For each panel, data are expressed as mean plus S.D. Significance was determined using an unpaired Student’s t-test. P <0.01 indicated with ##.