Inflammatory immune responses to gut antigen in mesenteric adipose tissue impair glucose tolerance.

<p>OVA-sensitized (solid lines and symbols) or naïve (dashed lines, open symbols) mice were put on 1% OVA-containing high-fat diets for the indicated duration, and a glucose tolerance test was then performed on fasted mice. Glucose clearance was significantly impaired in sensitized BALB/c mice after 10 and 14 weeks (linear mixed model test for identical trajectories) and trended to significantly decrease in C57Bl/6 mice after 14 weeks.