Altered dietary protein intake influences indices of insulin-sensitivity in MS-<i>Slc7a5</i>-KO mice.

<p>(A) Representative results of blood glucose concentration (mmol/L) in mice after intraperitoneal glucose injection during glucose tolerance test (GTT) on mice fed a 30% protein diet. (B) Quantitation of GTT responses presented as area-under-curve (AUC) for glucose disposal. Mean ± SEM for n = 5–7 (WT) and 4–5 (MS-<i>Slc7a5</i>-KO) male mice: 2-way ANOVA shows significant effects of genotype (<i>F</i> (1, 24) = 8.62, <i>p</i> = .007) on AUC: Statistically-significant differences between genotype (*, p<0.05) are indicated. (C) Gonadal epididymal fat mass of male mice at time of tissue sampling. Mean ± SEM for n = 6–7 (WT) and 4–5 (MS-<i>Slc7a5</i>-KO) mice. 2-way ANOVA reveals a significant effect of genotype (<i>F</i> (1, 27) = 6.54, <i>p</i> = .016) on gonadal fat mass, but the difference does not achieve p<0.05 at any specific protein intake.