Obese TSP1-/- mice had improved glucose tolerance and insulin sensitivity.

<p>Male TSP1-/- mice and wild type littermate controls were fed LF or HF diet for 16 weeks. Intraperitoneal glucose tolerance (A) and insulin sensitivity test (B) were measured. Changes in blood glucose levels were monitored over time. Data are represented as mean±SE (n = 10 mice/group). *P<0.05 vs. WT HF group. AUC: area under the curve.