Normalization of the <i>Dyrk1A</i> copy number rescued LTP in TS mice.

<p>(<b>a</b>) Representative fEPSP traces before (gray) and after (black) TBS stimulation (top row). (<b>b</b>) Time courses of the initial slope of fEPSPs recorded from the CA1 region in hippocampal slices following stimulation of the Schaffer collateral-commissural pathway. The data are presented as the mean values ± SEM from 6 slices from 6 different mice in each group (lower row). ANOVA ‘<i>trisomy</i>’: F(1,17) = 9.34, p = 0.009; ‘<i>Dyrk1A</i>’: F(1,17) = 13.62, p = 0.003.