Reduction of the <i>Dyrk1A</i> gene copy number did not rescue the reduced DG volume, SGZ area or body weight in TS mice.

<p>Mean values ± SEM of the DG volume (<b>a</b>), SGZ area (<b>b</b>) and body weight (<b>c</b>) of TS +/+/+ and TS +/+/− mice and of euploid mice. DG volume: ANOVA ‘trisomy’: F(1,17) = 4.94, p = 0.043; ‘<i>Dyrk1A</i>’: F(1,17) = 0.13, p = 0.72. SGZ area: ANOVA ‘trisomy’: F(1,17) = 12.14, p = 0.003; ‘<i>Dyrk1A</i>’: F(1,17) = 0.01, p = 0.89. Body weight: ANOVA ‘trisomy’: F(1,31) = 62.98, p<0.001; ‘<i>Dyrk1A</i>’: F(1,31) = 1.31, p = 0.026. *: p<0.05, **: p<0.01, ***: p<0.001 TS vs. CO; Bonferroni tests after significant MANOVAs.