FHL1 reduces muscle wasting in dystrophic <i>FRG1</i> mice.

<p>(A) Representative X-ray images of the spine of mice from the indicated genotypes. (B) Whole body weight in 6-week-old mice; wild-type (n = 10); <i>FRG1</i> (n = 6); <i>FRG1</i>/<i>FHL1</i> (n = 9); and 12-week-old mice; wild-type (n = 11); <i>FRG1</i> (n = 12); <i>FRG1/FHL1</i> (n = 14). (C) Representative image of skinned hind limbs from <i>FRG1</i> and <i>FRG1</i>/<i>FHL1</i> mice. Arrows point to the quadriceps muscle to show the difference in muscle mass between the <i>FRG1</i> and <i>FRG1</i>/<i>FHL1</i> mice. (D) Representative images of various muscles dissected from wild type, <i>FRG1</i> and FRG1/<i>FHL1</i> mice. (E) Relative muscle weight from 6-week-old mice and 12-week-old mice. Data represents an average of the combined weights from 4 muscle groups (n = 6–10 mice per genotype for the tibialis anterior, quadriceps, triceps and trapezius) and is expressed relative to wild type muscle weight. Data represent the mean ± SEM; *p&lt; 0.05; **p&lt;0.005; ***p&lt;0.0005 determined by two-tailed Student’s T-test.