Ovariectomy differentially influences CA1 hippocampal synaptic transmission in female apoE TR mice.

<p>Input-output curves presenting fEPSP slope in response to increasing stimulus input in apoE3 (A) and apoE4 (B) sham and OVX mice. (C) Average I/O slopes measured between 1 μA and 150 μA resulted in a significant increase in I/O slope in apoE4 OVX mice relative to sham (p = 0.0033). Long-term potentiation expressed as percent fEPSP slope normalized to baseline in apoE3 (D) and apoE4 (E) sham and OVX mice. Inset: representative traces of fEPSPs 5 min. before (gray line), and 40 min. after (black line) LTP induction from the designated mice. (F) Summarized magnitude of LTP representing the average percent potentiation of the last 20 minutes of recording. A two-way ANOVA resulted in a significant main effect of surgery (F_1,38 = 8.04, p<0.0073) and post-hoc tests revealed a significant reduction in LTP magnitude in apoE3 OVX mice relative to sham (*p = 0.019). Data are presented as mean ± SEM from 1–2 slices recorded from the following number of mice: apoE3 sham n = 6; apoE3 OVX n = 8; apoE4 sham n = 7; apoE4 OVX n = 7.