Normalization of the <i>Dyrk1A</i> copy number did not affect motor coordination in the rotarod test or the levels of general activity and anxiety in the open field test.

<p>Mean values ± SEM of the latency to fall from the rotarod at different constant speeds (<b>a</b>) and during the acceleration cycle (<b>b</b>) or of the activity performed by the three groups of mice in the open field test (<b>c</b>). Rotarod constant speeds: ANOVA ‘trisomy’: F(1,35) = 0.72, p = 0.40; ‘Dyrk1A’: F(1,35) = 1.82, p = 0.18. Acceleration cycle: ANOVA ‘trisomy’: F(1,35) = 0.72, p = 0.40; ‘Dyrk1A’: F(1,35) = 1.69, p = 0.20. Open field periphery: ANOVA ‘trisomy’: F(1,35) = 6.36, p = 0.014; ‘Dyrk1A’: F(1,35) = 0.70, p = 0.17; Center: ANOVA ‘trisomy’: F(1,31) = 2.21, p = 0.14; ‘Dyrk1A’: F(1,31) = 0.17, p = 0.68; Total: ANOVA ‘trisomy’: F(1,35) = 5.39, p = 0.023; ‘Dyrk1A’: F(1,35) = 1.77, p = 0.67. *: p<0.05 TS +/+/+ vs. CO +/+; Bonferroni tests after significant MANOVAs.