Pharmacological intervention via inhibition of IL-1 signaling improves the glucose tolerance in DIO mice.

<p>Wild type mice were fed a HFD for 13 weeks. At 32 days prior to sacrifice, mice were started on daily injections of IL-1Ra (Anakinra; 32 mg/kg) or saline by i.p. administration. Data are representative of 10 mice per group. At the end of 13 weeks, Anakinra-treated mice displayed no changes in <i>A.</i>) total animal body weight and were more glucose tolerant as demonstrated by a reduction in <i>B</i>.) area under the curve (AUC) for the intraperitoneal GTT and <i>C</i>.) fasting insulin levels. Values represent the mean ± SEM. An unpaired student’s t<i>-</i>test was used for comparisons between groups. <i>*</i>P≤0.05, **P≤0.01.