Sustained delivery of IL-1Ra from 25% PF127 gel prevents the extent of hyperglycemia in diabetic GK-rats.

<p>Treatment was started in 4 weeks old male wistar and GK-rats. 200 µl of NS was administered in wistar (n = 5) and GK (n = 5) rats once a day whereas, IL-1Ra (10 mg/kg body weight) in 200 µl presterilized PF127 gel in GK (n = 5) rats. Animal groups had different blood glucose values when the treatment was started (see text). IL-1Ra administration and measurement of blood glucose was performed at 9–10 am. (A) Delta (Δ) fed blood glucose, (B) AUC for Δ fed blood glucose values over 4 weeks of treatment, and (C) Δ bodyweight during treatment are shown. “n” represent the total number of animals in each group. ^*, P<0.05; ^**, P<0.01; compared to wistar rats groups. ^#, P<0.05; ^##, P<0.01 compared to GK-Saline group.