Additional file 1: Figure S1. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

Publication date

March 2016

DOI

10.6084/m9.figshare.c.3612563_d6.v1

Abstract

FC-IBC02 cell proliferation assays: estimated time trends in response to different CEP-37440 concentrations in the triple-negative IBC cell line FC-IBC02. (DOC 54 kb

Extracted data

We use cookies to provide a better user experience.

Data Protection

Additional file 1: Figure S1. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

Open link

Publication date

March 2016

DOI

10.6084/m9.figshare.c.3612563_d6.v1

Abstract

FC-IBC02 cell proliferation assays: estimated time trends in response to different CEP-37440 concentrations in the triple-negative IBC cell line FC-IBC02. (DOC 54 kb

Extracted data

Maud Verstraete (3431399)
Annelies Debucquoy (3431396)
Annelies Gonnissen (3431393)
Ruveyda Dok (3431402)
Sofie Isebaert (757211)
Ellen Devos (319514)
William McBride (486440)
Karin Haustermans (757212)

December 2015

Effect on cell survival and protein levels in HCA7 and HCT116 cells. (A) Effect of different concent...

Additional file 2: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S2. Anti-proliferative effect of RAD001 in combination with endocrine agents (a) 4-OHT and (b...

Additional file 1: Figure S1. of Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26

Murray Cutler (3452843)
Erica Lowthers (3452846)
Cynthia Richard (3452840)
Dagmar Hajducek (3452834)
Paul Spagnuolo (2058046)
Jonathan Blay (3452837)

November 2015

Anticancer agents decrease CXCR4+ cells and increase cell-surface expression of CD26 in the HT-29 ce...

Additional file 5: Figure S3. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

March 2016

SUM190 cell proliferation assays: estimated time trends in response to CEP-37440 concentration in th...

Additional file 9: Figure S5. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

March 2016

In vivo studies using SUM149 xenograft model: log-transformed tumor volumes and estimated time trend...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 1: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S1. GPER stimulation triggers FAK Y397 activation in SUM159 TNBC cells. Immunoblots showing F...

Additional file 2: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S2. The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin prevent respectively the acti...

Additional file 1: Figure S1. of Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells

Tomonori Tanei (3578141)
Dong Choi (3578132)
Angel Rodriguez (3563054)
Diana Liang (3578144)
Lacey Dobrolecki (3578129)
Madhumita Ghosh (3578138)
Melissa Landis (3578135)
Jenny Chang (3489839)

January 2016

Cetuximab treatment reduces autophagy. Western blot showed effects of cetuximab, ixabepilone, and co...

Additional file 2: of Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Yao Huang (216100)
David Burns (3843406)
Benjamin Rich (3843391)
Ian MacNeil (3843403)
Abhijit Dandapat (3179052)
Sajjad Soltani (3843400)
Samantha Myhre (3843397)
Brian Sullivan (337130)
Carol Lange (562170)
Leo Furcht (3843394)
Lance Laing (3843388)

March 2017

Figure S1. The PI3K/AKT pathway significantly contributes to the ligand-driven HER2 signaling activi...

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 3: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Murugan Kalimutho (6375365)
Debottam Sinha (6375368)
Deepak Mittal (4967743)
Sriganesh Srihari (3542939)
Devathri Nanayakkara (6375371)
Shagufta Shafique (759049)
Prahlad Raninga (6375374)
Purba Nag (6375377)
Kate Parsons (6375380)
Kum Khanna (3588107)

February 2019

Figure S2: (A) Hs578T cells were exposed to different concentrations of MEK1/2 inhibitor (AZD6244) a...

Additional file 4: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S4. The GPER antagonist G-15 and the FAK inhibitor VS-4718 inhibit the migration of SUM159 TN...

Additional file 1: Figure e1. of In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

Maud Verstraete (3431399)
Annelies Debucquoy (3431396)
Annelies Gonnissen (3431393)
Ruveyda Dok (3431402)
Sofie Isebaert (757211)
Ellen Devos (319514)
William McBride (486440)
Karin Haustermans (757212)

December 2015

Effect on cell survival and protein levels in HCA7 and HCT116 cells. (A) Effect of different concent...

Additional file 2: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S2. Anti-proliferative effect of RAD001 in combination with endocrine agents (a) 4-OHT and (b...

Additional file 1: Figure S1. of Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26

Murray Cutler (3452843)
Erica Lowthers (3452846)
Cynthia Richard (3452840)
Dagmar Hajducek (3452834)
Paul Spagnuolo (2058046)
Jonathan Blay (3452837)

November 2015

Anticancer agents decrease CXCR4+ cells and increase cell-surface expression of CD26 in the HT-29 ce...

Additional file 5: Figure S3. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

March 2016

SUM190 cell proliferation assays: estimated time trends in response to CEP-37440 concentration in th...

Additional file 9: Figure S5. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Israa Salem (3465863)
Manal Alsalahi (3465866)
Inna Chervoneva (3465854)
Lucy Aburto (3465857)
Sankar Addya (127326)
Gregory Ott (3465851)
Bruce Ruggeri (2080048)
Massimo Cristofanilli (243748)
Sandra Fernandez (3465860)

March 2016

In vivo studies using SUM149 xenograft model: log-transformed tumor volumes and estimated time trend...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 1: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S1. GPER stimulation triggers FAK Y397 activation in SUM159 TNBC cells. Immunoblots showing F...

Additional file 2: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S2. The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin prevent respectively the acti...

Additional file 1: Figure S1. of Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells

Tomonori Tanei (3578141)
Dong Choi (3578132)
Angel Rodriguez (3563054)
Diana Liang (3578144)
Lacey Dobrolecki (3578129)
Madhumita Ghosh (3578138)
Melissa Landis (3578135)
Jenny Chang (3489839)

January 2016

Cetuximab treatment reduces autophagy. Western blot showed effects of cetuximab, ixabepilone, and co...

Additional file 2: of Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Yao Huang (216100)
David Burns (3843406)
Benjamin Rich (3843391)
Ian MacNeil (3843403)
Abhijit Dandapat (3179052)
Sajjad Soltani (3843400)
Samantha Myhre (3843397)
Brian Sullivan (337130)
Carol Lange (562170)
Leo Furcht (3843394)
Lance Laing (3843388)

March 2017

Figure S1. The PI3K/AKT pathway significantly contributes to the ligand-driven HER2 signaling activi...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Expression of different markers in various breast cancer cell lines. Western blot showing different ...

Additional file 3: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Murugan Kalimutho (6375365)
Debottam Sinha (6375368)
Deepak Mittal (4967743)
Sriganesh Srihari (3542939)
Devathri Nanayakkara (6375371)
Shagufta Shafique (759049)
Prahlad Raninga (6375374)
Purba Nag (6375377)
Kate Parsons (6375380)
Kum Khanna (3588107)

February 2019

Figure S2: (A) Hs578T cells were exposed to different concentrations of MEK1/2 inhibitor (AZD6244) a...

Additional file 4: of Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Rigiracciolo (822024)
Maria Santolla (6310109)
Rosamaria Lappano (231412)
Adele Vivacqua (6310112)
Francesca Cirillo (2007373)
Giulia Galli (385878)
Marianna Talia (6310115)
Lucia Muglia (6310118)
Michele Pellegrino (6310121)
Nijiro Nohata (521198)
Maria Martino (6310124)
Marcello Maggiolini (231430)

February 2019

Figure S4. The GPER antagonist G-15 and the FAK inhibitor VS-4718 inhibit the migration of SUM159 TN...

Additional file 1: Figure e1. of In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

Maud Verstraete (3431399)
Annelies Debucquoy (3431396)
Annelies Gonnissen (3431393)
Ruveyda Dok (3431402)
Sofie Isebaert (757211)
Ellen Devos (319514)
William McBride (486440)
Karin Haustermans (757212)

December 2015

Effect on cell survival and protein levels in HCA7 and HCT116 cells. (A) Effect of different concent...

Additional file 2: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S2. Anti-proliferative effect of RAD001 in combination with endocrine agents (a) 4-OHT and (b...

Additional file 1: Figure S1. of Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26

Murray Cutler (3452843)
Erica Lowthers (3452846)
Cynthia Richard (3452840)
Dagmar Hajducek (3452834)
Paul Spagnuolo (2058046)
Jonathan Blay (3452837)

November 2015

Anticancer agents decrease CXCR4+ cells and increase cell-surface expression of CD26 in the HT-29 ce...

Additional file 1: Figure S1. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Abstract

Extracted data

Additional file 1: Figure S1. of The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

Abstract

Extracted data

Related items

Related items