Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

Publication date

February 2019

DOI

10.6084/m9.figshare.7733924.v1

Abstract

Expression of different markers in various breast cancer cell lines. Western blot showing different proteins expressed in various subtypes of 15 breast cancer cell lines. (PDF 1167 kb

Extracted data

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Data Protection

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

Open link

Publication date

February 2019

DOI

10.6084/m9.figshare.7733924.v1

Abstract

Expression of different markers in various breast cancer cell lines. Western blot showing different proteins expressed in various subtypes of 15 breast cancer cell lines. (PDF 1167 kb

Extracted data

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S1. IC50 values for the anti-proliferative effect of RAD001 and neratinib in relation to the ...

Additional file 2: of Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Yanzhong Wang (51838)
Jin Zeng (196246)
Weiping Wu (534670)
Shuduo Xie (424186)
Haitao Yu (456678)
Guoli Li (291427)
Tao Zhu (118644)
Fengying Li (405393)
Jie Lu (139953)
Gavin Wang (6711896)
Xinyou Xie (132868)
Jun Zhang (48506)

May 2019

Figure S1. Expression of NNMT in breast cancer cells and the cell models of SK-BR-3, MCF7, and MDA-M...

Additional file 2: of MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Yueh-Shan Weng (6477854)
Hong-Yu Tseng (6477857)
Yen-An Chen (6477860)
Pei-Chun Shen (6477863)
Aushia Haq (6477866)
Li-Mei Chen (47129)
Yi-Chung Tung (263328)
Hsin-Ling Hsu (169102)

March 2019

Figure S2. MCT-1 overexpression increases size of the MCF-10A acini. (PDF 223 kb

Additional file 3: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

IC50 of MEDI3039 and GST-TRAIL in multiple breast cancer cell lines with different subtypes. N.D. = ...

Additional file 5: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Histology analysis of extra MFP tumor developed in later stage in a mouse treated with MEDI3039. (A)...

Additional file 1: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 6: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 inhibited tumor metastases and extended animal survival in MB231T lung metastasis model. Th...

Additional file 4 of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

First MEDI3039 experiment in MFP model. This experiment was performed prior to dose-response experim...

Additional file 1: of A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer

Lucia D’Amico (6248780)
Ulrike Menzel (561225)
Michael Prummer (2671843)
Philipp Müller (93491)
Mélanie Buchi (6248783)
Abhishek Kashyap (6248786)
Ulrike Haessler (561228)
Alexander Yermanos (6248789)
Rémy Gébleux (6248792)
Manfred Briendl (6248795)
Tamara Hell (764058)
Fabian Wolter (6248798)
Roger Beerli (6248801)
Iva Truxova (6067376)
Špíšek Radek (6248804)
Tatjana Vlajnic (3070629)
Ulf Grawunder (764060)
Sai Reddy (6248807)
Alfred Zippelius (805066)

January 2019

Figure S1 Generation of a murine EMT6-hHER2 breast cancer cell line. A, Human-HER2 expression in EMT...

Additional file 2: of NUP98 â a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

Paul Mullan (6534653)
Victoria Bingham (6534656)
Paula Haddock (6534659)
Gareth Irwin (4235590)
Elaine Kay (414758)
Stephen McQuaid (81940)
Niamh Buckley (6534662)

April 2019

Figure S1. (A) Kaplan Meier plot of overall survival of TNBC patients from in-house datasets dichoto...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 2: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S2.The impact of TRAIL and TNF-alpha treatment in SKBR3-Par, -L and the impact of TRAIL in HC...

Additional file 2: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S2. Anti-proliferative effect of RAD001 in combination with endocrine agents (a) 4-OHT and (b...

Additional file 3: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S3. TRAIL expression in SKBR3-Par and SKBR3-L cells. A) TRAIL 1 and TRAIL 2 receptor expressi...

Additional file 1: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S1. IC50 values for the anti-proliferative effect of RAD001 and neratinib in relation to the ...

Additional file 2: of Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Yanzhong Wang (51838)
Jin Zeng (196246)
Weiping Wu (534670)
Shuduo Xie (424186)
Haitao Yu (456678)
Guoli Li (291427)
Tao Zhu (118644)
Fengying Li (405393)
Jie Lu (139953)
Gavin Wang (6711896)
Xinyou Xie (132868)
Jun Zhang (48506)

May 2019

Figure S1. Expression of NNMT in breast cancer cells and the cell models of SK-BR-3, MCF7, and MDA-M...

Additional file 2: of MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Yueh-Shan Weng (6477854)
Hong-Yu Tseng (6477857)
Yen-An Chen (6477860)
Pei-Chun Shen (6477863)
Aushia Haq (6477866)
Li-Mei Chen (47129)
Yi-Chung Tung (263328)
Hsin-Ling Hsu (169102)

March 2019

Figure S2. MCT-1 overexpression increases size of the MCF-10A acini. (PDF 223 kb

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

IC50 of MEDI3039 and GST-TRAIL in multiple breast cancer cell lines with different subtypes. N.D. = ...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

Histology analysis of extra MFP tumor developed in later stage in a mouse treated with MEDI3039. (A)...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 inhibited tumor metastases and extended animal survival in MB231T lung metastasis model. Th...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

First MEDI3039 experiment in MFP model. This experiment was performed prior to dose-response experim...

Additional file 1: of A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer

Lucia D’Amico (6248780)
Ulrike Menzel (561225)
Michael Prummer (2671843)
Philipp Müller (93491)
Mélanie Buchi (6248783)
Abhishek Kashyap (6248786)
Ulrike Haessler (561228)
Alexander Yermanos (6248789)
Rémy Gébleux (6248792)
Manfred Briendl (6248795)
Tamara Hell (764058)
Fabian Wolter (6248798)
Roger Beerli (6248801)
Iva Truxova (6067376)
Špíšek Radek (6248804)
Tatjana Vlajnic (3070629)
Ulf Grawunder (764060)
Sai Reddy (6248807)
Alfred Zippelius (805066)

January 2019

Figure S1 Generation of a murine EMT6-hHER2 breast cancer cell line. A, Human-HER2 expression in EMT...

Additional file 2: of NUP98 â a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

Paul Mullan (6534653)
Victoria Bingham (6534656)
Paula Haddock (6534659)
Gareth Irwin (4235590)
Elaine Kay (414758)
Stephen McQuaid (81940)
Niamh Buckley (6534662)

April 2019

Figure S1. (A) Kaplan Meier plot of overall survival of TNBC patients from in-house datasets dichoto...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 2: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S2.The impact of TRAIL and TNF-alpha treatment in SKBR3-Par, -L and the impact of TRAIL in HC...

Additional file 2: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S2. Anti-proliferative effect of RAD001 in combination with endocrine agents (a) 4-OHT and (b...

Additional file 3: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S3. TRAIL expression in SKBR3-Par and SKBR3-L cells. A) TRAIL 1 and TRAIL 2 receptor expressi...

Additional file 1: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

Ricardo Ribas (222948)
Sunil Pancholi (222942)
Aradhana Rani (529007)
Eugene Schuster (12754)
Stephanie Guest (5350772)
Joanna Nikitorowicz-Buniak (776212)
Nikiana Simigdala (424363)
Allan Thornhill (5350766)
Francesca Avogadri-Connors (5350769)
Richard Cutler (5350763)
Alshad Lalani (5350775)
Mitch Dowsett (645)
Stephen Johnston (767275)
Lesley-Ann Martin (222958)

June 2018

Figure S1. IC50 values for the anti-proliferative effect of RAD001 and neratinib in relation to the ...

Additional file 2: of Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Yanzhong Wang (51838)
Jin Zeng (196246)
Weiping Wu (534670)
Shuduo Xie (424186)
Haitao Yu (456678)
Guoli Li (291427)
Tao Zhu (118644)
Fengying Li (405393)
Jie Lu (139953)
Gavin Wang (6711896)
Xinyou Xie (132868)
Jun Zhang (48506)

May 2019

Figure S1. Expression of NNMT in breast cancer cells and the cell models of SK-BR-3, MCF7, and MDA-M...

Additional file 2: of MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Yueh-Shan Weng (6477854)
Hong-Yu Tseng (6477857)
Yen-An Chen (6477860)
Pei-Chun Shen (6477863)
Aushia Haq (6477866)
Li-Mei Chen (47129)
Yi-Chung Tung (263328)
Hsin-Ling Hsu (169102)

March 2019

Figure S2. MCT-1 overexpression increases size of the MCF-10A acini. (PDF 223 kb

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Abstract

Extracted data

Additional file 2: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Abstract

Extracted data

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