(A) It showed the histological appearance of the newborn mouse ovarian tissue (Scale bars: 50 μm) and ovary whole-mount substratesimmunofluorescence (Scale bars: 100 μm) with MVH antibody in control and STZ-treated groups at PND 1. Oocytes are stained with MVH (red) and Hoechst33342 (blue) to label the nucleus. (B) It showed the percentage of oocytes in cyst and primordial follicle in control and STZ-treated groups at PND 1. At least 5 mice were analyzed in each group; Date are presented as mean ± SEM. *shows a significant difference between STZ-treated and control at P < 0.05; ** shows a significant difference at P < 0.01.</p
<p><i>A:</i> Immunofluorescence staining showing α-cell expansion following STZ treatment. The pancr...
Post-translational modification of proteins namely glycosylation influences cellular behavior, struc...
(A-E) Relative expression levels of oocyte-specific genes including Lhx8, Nobox, Sohlh2, Figla and K...
(A) The histological appearance (Scale bars: 50 μm) and ovary whole-mount substratesimmunofluorescen...
(A, B) Real-time PCR analysis of the mRNA expression levels of insulin receptor and PI3K gene in con...
(A) The glucose concentrations in STZ-treated and control mice in 3 weeks. The average glucose conce...
Type 1 diabetes (T1D) is a common disease in which pancreatic β cells are impaired due to auto-immun...
<p>(A–C) Mouse ovaries at postnatal day 0. Sections from MRL/MpJ (panel A), DBA/2 (panel B), and C57...
(A) The diabetic mouse ovaries showed strong follicular degeneration associated with follicular apop...
<p>(A–C) The ovaries of MRL/MpJ mice at postnatal day 0. Immunohistochemical analysis of F4/80 (macr...
(A-F) Real-time PCR analysis of mRNA expression levels of Nobox, Figla, Sohlh2, PI3K and Insulin and...
<p>(<b>A, B</b>)<b>:</b> TUNEL-analysis to determine apoptosis in primordial follicles. (<b>A</b>)<b...
<p>(A–B) Representative images of insulin immunofluorescence on islets from a floxed control (A) and...
<p>(A and C) Graphs depicting the incidence of diabetes in mice with the indicated genotypes after t...
<p>(A) Representative images of hematoxylin and eosin (H&E) stained cross-sections of ovaries from P...
<p><i>A:</i> Immunofluorescence staining showing α-cell expansion following STZ treatment. The pancr...
Post-translational modification of proteins namely glycosylation influences cellular behavior, struc...
(A-E) Relative expression levels of oocyte-specific genes including Lhx8, Nobox, Sohlh2, Figla and K...
(A) The histological appearance (Scale bars: 50 μm) and ovary whole-mount substratesimmunofluorescen...
(A, B) Real-time PCR analysis of the mRNA expression levels of insulin receptor and PI3K gene in con...
(A) The glucose concentrations in STZ-treated and control mice in 3 weeks. The average glucose conce...
Type 1 diabetes (T1D) is a common disease in which pancreatic β cells are impaired due to auto-immun...
<p>(A–C) Mouse ovaries at postnatal day 0. Sections from MRL/MpJ (panel A), DBA/2 (panel B), and C57...
(A) The diabetic mouse ovaries showed strong follicular degeneration associated with follicular apop...
<p>(A–C) The ovaries of MRL/MpJ mice at postnatal day 0. Immunohistochemical analysis of F4/80 (macr...
(A-F) Real-time PCR analysis of mRNA expression levels of Nobox, Figla, Sohlh2, PI3K and Insulin and...
<p>(<b>A, B</b>)<b>:</b> TUNEL-analysis to determine apoptosis in primordial follicles. (<b>A</b>)<b...
<p>(A–B) Representative images of insulin immunofluorescence on islets from a floxed control (A) and...
<p>(A and C) Graphs depicting the incidence of diabetes in mice with the indicated genotypes after t...
<p>(A) Representative images of hematoxylin and eosin (H&E) stained cross-sections of ovaries from P...
<p><i>A:</i> Immunofluorescence staining showing α-cell expansion following STZ treatment. The pancr...
Post-translational modification of proteins namely glycosylation influences cellular behavior, struc...
(A-E) Relative expression levels of oocyte-specific genes including Lhx8, Nobox, Sohlh2, Figla and K...