Additional file 1: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

Publication date

April 2018

DOI

10.6084/m9.figshare.6147317.v1

Abstract

Figure S1. Cell death was dose-dependently increased by the addition of ILz:rhTRAIL. Cells were cultured onto 96-well plates and treated with serially increasing amount of recombinant TRAIL proteins: rmT, rmTRAIL; rhT, rhTRAIL; ILz:T, ILz:rhTRAIL. Cell survival was examined by XTT assay after 24Â h. (TIFF 134 kb

Extracted data

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Additional file 1: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

Open link

Publication date

April 2018

DOI

10.6084/m9.figshare.6147317.v1

Abstract

Extracted data

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death....

Additional file 1: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda (816958)
Hiroshi Fujii (289510)
Masato Nose (1272312)
Yukiko Kamogawa (4351870)
Tsuyoshi Shirai (3938939)
Yuko Shirota (4351867)
Tomonori Ishii (186302)
Hideo Harigae (133506)

August 2017

is a table presenting significantly upregulated and downregulated genes in spleens of Bz-treated and...

Additional file 3: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S3. Cell death inducing ability of bortezomib was analyzed in TRAIL-resistant cells. Four TRA...

Additional file 7: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S7. Cell death was not regulated by the addition of SP600125 in ILz:rhTRAIL treated cells. (A...

Additional file 5: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S5. Combined treatment-induced cell death was not inhibited by the addition of ER stress inhi...

Additional file 6: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S6. Combined treatment-induced cell death was not inhibited by the addition of autophagy inhi...

Additional file 3: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S2. Knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death. MCL cell line ...

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu
Yun Jeong Ahn
Chakeong Yoon
Jeong Hwan Chang
Yoonkyung Park
Tae-Hyoung Kim
Amanda R. Howland
Cheryl A. Armstrong
Peter I. Song
Ae Ran Moon

April 2018

Abstract Background Multiple trials have attempted to demonstrate the effective induction of cell de...

Additional file 1: of MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 1: of Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms

Tri Nguyen (1724989)
Rebecca Parker (5984135)
Yu Zhang (12946)
Elisa Hawkins (5984138)
Maciej Kmieciak (494185)
William Craun (5984141)
Steven Grant (380210)

November 2018

HHT dramatically increases bortezomib lethality and inhibits cell growth in DLBCL cells. A) SU-DHL4 ...

Additional file 4: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S3. Double knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death similar ...

Additional file 10: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S9. Co-treatment of bortezomib with autophagy inhibitors potentiates cell death induction. MC...

Additional file 4: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda (816958)
Hiroshi Fujii (289510)
Masato Nose (1272312)
Yukiko Kamogawa (4351870)
Tsuyoshi Shirai (3938939)
Yuko Shirota (4351867)
Tomonori Ishii (186302)
Hideo Harigae (133506)

August 2017

is a figure showing in-vitro induction of HSPA1A (HSP70) and HSPB1 (HSP27) expression in Bz-treated ...

Additional file 7: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S6. Palbociclib-mediated antagonism on bortezomib-induced cell death is not caused by alterat...

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death....

Additional file 1: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda (816958)
Hiroshi Fujii (289510)
Masato Nose (1272312)
Yukiko Kamogawa (4351870)
Tsuyoshi Shirai (3938939)
Yuko Shirota (4351867)
Tomonori Ishii (186302)
Hideo Harigae (133506)

August 2017

is a table presenting significantly upregulated and downregulated genes in spleens of Bz-treated and...

Additional file 3: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S3. Cell death inducing ability of bortezomib was analyzed in TRAIL-resistant cells. Four TRA...

Additional file 7: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S7. Cell death was not regulated by the addition of SP600125 in ILz:rhTRAIL treated cells. (A...

Additional file 5: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S5. Combined treatment-induced cell death was not inhibited by the addition of ER stress inhi...

Additional file 6: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu (773394)
Yun Ahn (5106824)
Chakeong Yoon (5106815)
Jeong Chang (3766879)
Yoonkyung Park (199734)
Tae-Hyoung Kim (506760)
Amanda Howland (5106818)
Cheryl Armstrong (5106821)
Peter Song (5106830)
Ae Moon (5106827)

April 2018

Figure S6. Combined treatment-induced cell death was not inhibited by the addition of autophagy inhi...

Additional file 3: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S2. Knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death. MCL cell line ...

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu
Yun Jeong Ahn
Chakeong Yoon
Jeong Hwan Chang
Yoonkyung Park
Tae-Hyoung Kim
Amanda R. Howland
Cheryl A. Armstrong
Peter I. Song
Ae Ran Moon

April 2018

Abstract Background Multiple trials have attempted to demonstrate the effective induction of cell de...

Yoshimi Greer (6374504)
Samuel Gilbert (6374507)
Brunilde Gril (202357)
Rajesh Narwal (4425985)
Danielle Peacock Brooks (6374510)
David Tice (3173028)
Patricia Steeg (6374513)
Stanley Lipkowitz (253942)

February 2019

MEDI3039 induces cell death in TNBC cell lines. (A) Western blot showing time-dependent effect of ME...

Additional file 1: of Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms

Tri Nguyen (1724989)
Rebecca Parker (5984135)
Yu Zhang (12946)
Elisa Hawkins (5984138)
Maciej Kmieciak (494185)
William Craun (5984141)
Steven Grant (380210)

November 2018

HHT dramatically increases bortezomib lethality and inhibits cell growth in DLBCL cells. A) SU-DHL4 ...

Additional file 4: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S3. Double knockdown of cyclin D1 and CDK4 antagonizes bortezomib-induced cell death similar ...

Additional file 10: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S9. Co-treatment of bortezomib with autophagy inhibitors potentiates cell death induction. MC...

Additional file 4: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda (816958)
Hiroshi Fujii (289510)
Masato Nose (1272312)
Yukiko Kamogawa (4351870)
Tsuyoshi Shirai (3938939)
Yuko Shirota (4351867)
Tomonori Ishii (186302)
Hideo Harigae (133506)

August 2017

is a figure showing in-vitro induction of HSPA1A (HSP70) and HSPB1 (HSP27) expression in Bz-treated ...

Additional file 7: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S6. Palbociclib-mediated antagonism on bortezomib-induced cell death is not caused by alterat...

Additional file 11: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus Giménez (5718941)
Kathrin Böpple (4332913)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S10. Synergistic cell death after proteasome inhibition and simultaneous fatty acid inhibitio...

Additional file 13: of Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Simon Heine (5718920)
Markus Kleih (5718926)
Neus GimĂŠnez (5718929)
Kathrin BĂśpple (5718932)
German Ott (216544)
Dolors Colomer (1593736)
Walter Aulitzky (5718935)
Heiko van der Kuip (52857)
Elisabeth Silkenstedt (5718938)

September 2018

Figure S12. Proteasome inhibitors combined with fatty acid inhibition induce synergistic cell death....

Additional file 1: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda (816958)
Hiroshi Fujii (289510)
Masato Nose (1272312)
Yukiko Kamogawa (4351870)
Tsuyoshi Shirai (3938939)
Yuko Shirota (4351867)
Tomonori Ishii (186302)
Hideo Harigae (133506)

August 2017

is a table presenting significantly upregulated and downregulated genes in spleens of Bz-treated and...

Additional file 1: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Abstract

Extracted data

Additional file 1: of The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Abstract

Extracted data

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