Cellular networks of candidate genes.

<p>(A) Enriched cellular genetic pathway for candidate genes from all genome wide association analyses (gray squares), allowing one missing gene (white triangles) or compound (white circles). The border colors indicate the over-represented gene ontology categories (<i>P</i><0.005): axon guidance (red), synapse organization (orange), protein phosphorylation (magenta), signal transduction (dark green), inositol phosphate metabolism (yellow), phagocytosis engulfment (dark blue), regulation of cell shape (light blue), actin cytoskeleton organization (light green), and potassium ion transport (pink). Drosophila genes with human homologs are indicated in red font. (B) Enriched network for human homologs of Drosophila candidate genes (gray squares) missing no more than two consecutive genes (white triangles) or compounds (white circles). The border colors indicate the over-represented gene ontology categories (<i>P</i> = 0.085): Rho GTPase signaling (orange), NGF signaling (red), EGFR signaling (olive green), synaptic transmission (light green), integrin cell surface interactions (dark green), DNA replication (magenta), inositol phosphate metabolism (yellow), integration of energy metabolism (light pink), metabolism of vitamins and cofactors (dark blue), glycerolipid metabolism (light blue), and metabolism of carbohydrates (light purple).