Molecular network generated by Ingenuity software from the statistically significantly different expressed genes.

<p>Molecular network generated from our microarray <i>Significantly Different Expressed sub-dataset.</i> Red fields indicate genes statistically significantly higher expressed in PE compared to NPE whereas green fields indicate genes statistically significantly higher expressed in NPE compared to PE. Solid lines between molecules indicate direct physical relationships between molecules (such as regulating and interacting protein domains); dotted lines indicate indirect functional relationships (such as co-regulation of expression of both genes in cell lines). Abbreviations of gene names are according to standard abbreviations used in Genbank. The main functionalities given by Ingenuity for this molecular network are ‘Connective tissue development and function, skeletal and muscular system development and function, cardiovascular disease’. Highlight in this network is the presence of many genes that are involved in developmental process, namely NOTCH2, GATA6, HEY1, HEY2 and GDF11.