Illustration of selected enriched pathways in the differential network of each breast cell state.

<p>(A) S1; (B) T4; (C) the EGFR/ITGB1-T4R group; (D) the PI3K/MAPKK-T4R group; and (E) the MMP-T4R group. In each plot, the differential network for the corresponding cell state is shown. Nodes represent genes; edges represent interaction of the genes. Selected pathways enriched in the network (unadjusted p-values<0.05) are color-coded and shown on the right; genes participating in the selected pathways are also colored based on the color code for the corresponding pathway. An asterisk indicates a pathway that is significantly enriched in the corresponding differential network. The pathway names are shortened to save space. See <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003713#pcbi.1003713.s008" target="_blank">Table S1</a> for detailed information about the enriched pathways in each cell state.