Effects of cholecystokinin on the FPLC profile of plasma cholesterol.

<p>Wild-type (<b>A and C</b>) and <i>LDLR^−/−</i> (<b>B and D</b>) mice were intravenously injected with 50 ng/kg of cholecystokinin (CCK) or an equal volume of PBS as a control. Blood samples were collected at 2 h after CCK or vehicle injections. Mouse plasma was fractionated with a fast protein liquid chromatography (FPLC) system. Cholesterol levels in the VLDL, LDL and HDL fractions were determined with a colorimetric assay. Values represent the mean ± SEM of 5 mice per group. The difference between controls and CCK treatment was analyzed using Student's unpaired <i>t</i>-test. * <i>P</i><0.05 compared to control.