Effects of atherogenic diets on lipoprotein cholesterol profiles of HypoE mice.

<p>HypoE mice housed in groups (including one or more SRBI^+/−ApoeR61^h/h littermates per group, 4–5/cage) were fed Western (open/white symbols, n = 5), Paigen NC (gray symbols, n = 5) or Paigen (black symbols, n = 3) diets for one month starting at two months of age and then plasma was harvested and subjected to FPLC size fractionation. The data shown include only the HypoE mice. <b>A.</b> Averaged plasma lipoprotein total cholesterol (TC) profiles (mg/dL plasma). Brackets indicate the approximate elution positions of VLDL, intermediate-density lipoproteins (IDL)/LDL, and HDL. <b>(Inset)</b> Expanded scale for the IDL/LDL and HDL regions of the profiles. <b>B.</b> For each profile from individual mice, total cholesterol levels in the indicated pooled fractions corresponding to VLDL-, IDL/LDL- or HDL-size particles were summed and averages were calculated. Data are represented as mean ± SD. Statistically significant differences were determined by Kruskal-Wallis tests followed by the Dunn’s multiple comparison post-test. *p<0.05.