Expression of Sig-1R in OX-42⁺ cells in the ischemic hemisphere - Effect of SA4503 treatment.

<p>Sig-1R immunoreactivity in a vehicle (<b>A</b>) and SA4503 (<b>B</b>) treated animal after MCAO. In both animals Sig-1R (Cy3, red) is expressed in OX-42⁺ cells (Cy5, green) in the infarct core and adjacent peri-infarct area. Scale bars: 50 µm. (<b>C</b>) Western blot for the Sig-1R of samples from the ischemic infarct core from SA4503 (0.5 mg/kg s.c.) and vehicle treated rats and respective densitometric analyses (mean±SD, *p<0.05, t-test) at day 7 following MCAO. Each lane represents an individual animal and for densitometric analysis n = 8 rats were included for each treatment group.