Simvastatin decreased infact area of MCAO rats. A:

<p>representative photographs of brain slices; no infarct area detected in sham group. <b>B:</b> the fourth brain slice of each rat picked out for statistical analysis; MCAO and vehicle+MCAO group showing a significant lesion, but sim+MCAO group indicating improvement in infarct area; values expressed as means ± SEM of 6 rats; ##<i>P</i><0.01, sim+MCAO <i>vs</i>. MCAO group; &&<i>P</i><0.01, sim+MCAO <i>vs</i>. vehicle+MCAO group. Sim, Simvastatin.