Time course of microglial/macrophages activation after ischemia: effect of 3-AB treatment.

<p>Microglial/macrophages activation was assessed at 4 h, 24 h, 8 d, 15 d and 30 d of photothrombotic ischemia by immunostaining using anti-OX-42 antibody, recognizing type 3 complement receptors. Rats treated with 3-AB showed an important decrease in microglial/macrophages activation in the acute phase of ischemia (B1–2 and D1–2). At longer time points, no differences were observed between vehicle (E, G, I) and 3-AB treated animals (F, H, J). Photomicrographs are representative of 6 to 11 animals at each time point. Scale bar = 200 µm in panels 1, 40 µm in panels 2 and 50 µm (insert).