Changes in levels of dopamine and its main metabolites in samples of brain striatum from MPTP treated mice.

<p>The degree of dopaminergic neurodegeneration caused by MPTP administration was evaluated by examining the levels of dopamine (A), DOPAC (B), and HVA (C). As a control, the effect of MPTP administration on noradrenaline levels (D) was also evaluated in the same samples. Results of striatum values from control and MPTP treated mice were analyzed by ANOVA followed by Tukey’s post-hoc test. Lowercase letters above the bars indicate the results of that analysis; values that share any letter in common are not significantly different (P ≥ 0.05), and values that do not share any letter in common are significantly different (P < 0.05).