<p>Striatal levels of dopamine and its metabolites measured after 2 weeks of acute 2′NH<sub>2</sub>MPTP (15 mg/kg, i.p.) administered four times every two hours in wild type and α-synuclein knock out mice. Data are expressed as mean (n = 5) ± SEM. Statistical analysis was performed by ANOVA, revealing no significant differences among group means. DA, dopamine; DOPAC, 3,4-dihydroxy-phenylacetic acid; HVA, homovanillic acid, WT, wild type; KO, knock out.</p
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
<p>The degree of dopaminergic neurodegeneration caused by MPTP administration was evaluated by exami...
<p><b>A)</b> Levels of striatal dopamine were significantly reduced following MPTP intoxication. How...
<p>Transgenic mice expressing moderate levels (∼3-fold over endogenous levels) of wild type (WT, lin...
<p>Animals received one daily i.p. injection of saline or MPTP (30 mg/kg) for five consecutive days ...
<p>Protein blots for striatal TH were analyzed TH/β-actin ratio and normalized by the results of CON...
<p>Effect of MPTP and PPI-1011 treatment on striatal A) dopamine (DA) contents (<i>F</i><sub>4,46</s...
<p>(A) Striatal dopamine content following MPTP or saline administration. * p<0.05. (B) TH content m...
<p><b><i>A.</i></b> Expression of mouse and human α-synuclein in wild type (WT), mouse α-synuclein n...
<p>Striatal DA levels were estimated by HPLC in these mice at 14 days after MPTP or saline injection...
<p>Effect of MPTP and PPI-1011 treatment on striatal A) DA contents (<i>F</i><sub>4,49</sub> = 15.76...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
<p>The degree of dopaminergic neurodegeneration caused by MPTP administration was evaluated by exami...
<p><b>A)</b> Levels of striatal dopamine were significantly reduced following MPTP intoxication. How...
<p>Transgenic mice expressing moderate levels (∼3-fold over endogenous levels) of wild type (WT, lin...
<p>Animals received one daily i.p. injection of saline or MPTP (30 mg/kg) for five consecutive days ...
<p>Protein blots for striatal TH were analyzed TH/β-actin ratio and normalized by the results of CON...
<p>Effect of MPTP and PPI-1011 treatment on striatal A) dopamine (DA) contents (<i>F</i><sub>4,46</s...
<p>(A) Striatal dopamine content following MPTP or saline administration. * p<0.05. (B) TH content m...
<p><b><i>A.</i></b> Expression of mouse and human α-synuclein in wild type (WT), mouse α-synuclein n...
<p>Striatal DA levels were estimated by HPLC in these mice at 14 days after MPTP or saline injection...
<p>Effect of MPTP and PPI-1011 treatment on striatal A) DA contents (<i>F</i><sub>4,49</sub> = 15.76...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on t...
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been shown to destroy the nigrostriatal d...