Quantification of striatal DA levels after MPTP or saline injection of WT, and hWT mice.

<p>Striatal DA levels were estimated by HPLC in these mice at 14 days after MPTP or saline injection. Data were reported as the mean±SEM. Two-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050063#pone-0050063-g007" target="_blank">Figure 7A</a>) and one-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050063#pone-0050063-g007" target="_blank">Figure 7B</a>) were used to assess significance. In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050063#pone-0050063-g007" target="_blank">Figure 7B</a>, the differences in the striatal DA level between the saline and MPTP treatment groups are expressed as a percentage of the matched saline control groups. There was a significant reduction in striatal DA level in each of the MPTP treatment groups compared with saline injection groups (***P<0.001) but the effect did not differ by genotype. The HCl salt form of MPTP was used in this experiment. Group sizes: WT/MPTP (n = 9); WT/Saline (n = 10); HWT/MPTP (n = 9) HWT/Saline (n = 10).