Striatal dopamine and turnover in MPTP-intoxicated mice following ND-602.

<p><b>A)</b> Levels of striatal dopamine were significantly reduced following MPTP intoxication. However, in those animals treated with viral vector delivery of PGRN by ND-602, no decline in dopamine was observed ipsilateral to vector delivery. Levels were reduced, however, in the contralateral, untreated, hemisphere. The dopamine metabolites, <b>B)</b> DOPAC and <b>C)</b> HVA, were similarly reduced by MPTP, with no reductions observed ipsilateral to ND-602 delivery. <b>D)</b> Striatal dopamine turnover was significantly elevated by MPTP intoxication. However, no change in turnover was observed ipsilateral to ND-602 treatment. Each bar represents the mean (±S.E.M., n = 5–8) µg of dopamine, DOPAC or HVA detected per gram of wet tissue weight. For dopamine turnover, the calculation, DOPAC + HVA/dopamine was applied. **sig. diff. from vehicle control, <i>p</i><0.001. ++sig. diff. from GFP control, <i>p</i><0.001.