Effect of MTA and A_2AR antagonists in an acute mouse model of PD.

<p>The effect of MTA (30 mg/kg), MSX-3 (9 mg/kg) or both in combination on the survival of dopaminergic neurons (TH⁺ cells) within the <i>substantia nigra</i> of the brain of mice treated with MPTP. a) Representative images of the neurodegeneration of dopaminergic cells in the different groups. b) Stereological counts of TH⁺ neurons in control and drug-treated animals (n = 6 per group). The data represent the mean±SEM: *<i>p</i><0.05 comparing with the MPTP group; # <i>p</i><0.05 comparing with the control group (One-way ANOVA, LSD test as a post-hoc). Scale bar: 50 µm.