Effects of STZ-induced insulin deficiency on APP processing in 5XFAD mice.

<p>(<i>A</i>) Western blot analysis of hemibrain lysates from vehicle- and STZ-treated 5XFAD mice. Immunoreactive bands for secretases involved in the APP cleavage (<i>B</i>), full-length APP (fl-APP) and its metabolites (<i>C</i>) were quantified and expressed as the percentage of vehicle-treated 5XFAD levels (<i>n</i> = 4–7 mice per group). BACE1, fl-APP and C99 levels were significantly increased, while sAPPα levels were significantly reduced in STZ-treated 5XFAD mice (*<i>p</i><0.05 vs. vehicle). All data are presented as mean ± SEM.