Expression level of APP cleavage enzymes and products in APP/PS1 mice.

<p>(<b>A</b>) The expression levels of ADAM10, BACE1 and PS1 in transgenic mouse brain were determined by Western blot analyses. GAPDH was used as an internal control. The level of ADAM10 was markedly reduced, whereas the level of BACE1 was significantly increased in Zn-treated mice, compared with controls. (<b>B</b>) Zinc treatment significantly reduced the level of sAPPα and C83, and increased the level of sAPPβ and C99 compared with the control group. ** <i>p</i><0.01 versus control group (Student's <i>t</i> test).