<p>(A) Glycemia (B) RT-qPCR analysis of mRNA levels. Upper left panel: POMC mRNA levels; upper middle panel: AgRP mRNA levels; upper right panel: NPY mRNA levels; lower left panel: Neuro-D mRNA levels; lower right panel: COUP-TFII mRNA levels. Citrate control mice (□), STZ treated mice (▪), STZ mice treated with insulin (grey square). Data are expressed as mean ± SEM. (<i>n</i> = 6 mice/group). *P≤0.05 **P≤0.01 compared to citrate treated mice. § P≤0.05 §§P≤0.01 compared to STZ treated mice.</p
<p>(<b>A</b>) Cumulative incidence of diabetes (random-fed blood glucose >250 mg/dl) in CF and Tfm t...
<p>(<b>A</b>) Left: Western blot of p<sup>Ser473</sup>-Akt and total Akt in ND- or HFD-fed mouse bra...
<p>A) Insulin tolerance test of <i>Ptprt</i><sup>+/+</sup> (n = 8) and <i>Ptprt</i><sup>−/−</sup> (n...
<p>(A) Blood glucose and plasma insulin (B-C) RT-qPCR analysis of mRNA levels in the hypothalamus of...
<p>(A-C) RT-qPCR analysis of mRNA levels from hypothalamus of <i>ad libitum</i> fed mice receiving a...
<p>C57BL/6J mice are either fasted for 24 h (□) or fasted 24 h and refed on a regular diet (▪). (A) ...
<p>(<i>A</i>) Western blot analysis of hemibrain lysates from vehicle- and STZ-treated 5XFAD mice. (...
<p>(<b>NY</b>)<b>, SCI young</b> (<b>SCIY</b>)<b>, naïve aged</b> (<b>NO</b>) <b>and SCI aged</b> (<...
1<p>Data are means ± SEM (n = 5–10). In each row values without a common letter significantly differ...
<p>(A–D) RT-qPCR analysis of mRNA from livers (A–B) or pancreas (C–D) of <i>ad libitum</i> fed mice ...
<p>Protein and mRNA were isolated from bisected sections of mediobasal hypothalamus of f/f and KO mi...
<p>A–C. Arcuate SOCS3 mRNA, PTP1B mRNA and TC-PTP mRNA in POMC-LepRb and control mice after 19 weeks...
<p>(<i>A</i>) Real-time qPCR revealed no difference in BACE1 mRNA levels between STZ- and vehicle-tr...
<p>Determinations by quantitative RT-PCR. The relative mRNA contents were measured in hypothalamus o...
<p>Legend: Gene expression was measured in hypothalamus on day 2 of macronutrient selection diet usi...
<p>(<b>A</b>) Cumulative incidence of diabetes (random-fed blood glucose >250 mg/dl) in CF and Tfm t...
<p>(<b>A</b>) Left: Western blot of p<sup>Ser473</sup>-Akt and total Akt in ND- or HFD-fed mouse bra...
<p>A) Insulin tolerance test of <i>Ptprt</i><sup>+/+</sup> (n = 8) and <i>Ptprt</i><sup>−/−</sup> (n...
<p>(A) Blood glucose and plasma insulin (B-C) RT-qPCR analysis of mRNA levels in the hypothalamus of...
<p>(A-C) RT-qPCR analysis of mRNA levels from hypothalamus of <i>ad libitum</i> fed mice receiving a...
<p>C57BL/6J mice are either fasted for 24 h (□) or fasted 24 h and refed on a regular diet (▪). (A) ...
<p>(<i>A</i>) Western blot analysis of hemibrain lysates from vehicle- and STZ-treated 5XFAD mice. (...
<p>(<b>NY</b>)<b>, SCI young</b> (<b>SCIY</b>)<b>, naïve aged</b> (<b>NO</b>) <b>and SCI aged</b> (<...
1<p>Data are means ± SEM (n = 5–10). In each row values without a common letter significantly differ...
<p>(A–D) RT-qPCR analysis of mRNA from livers (A–B) or pancreas (C–D) of <i>ad libitum</i> fed mice ...
<p>Protein and mRNA were isolated from bisected sections of mediobasal hypothalamus of f/f and KO mi...
<p>A–C. Arcuate SOCS3 mRNA, PTP1B mRNA and TC-PTP mRNA in POMC-LepRb and control mice after 19 weeks...
<p>(<i>A</i>) Real-time qPCR revealed no difference in BACE1 mRNA levels between STZ- and vehicle-tr...
<p>Determinations by quantitative RT-PCR. The relative mRNA contents were measured in hypothalamus o...
<p>Legend: Gene expression was measured in hypothalamus on day 2 of macronutrient selection diet usi...
<p>(<b>A</b>) Cumulative incidence of diabetes (random-fed blood glucose >250 mg/dl) in CF and Tfm t...
<p>(<b>A</b>) Left: Western blot of p<sup>Ser473</sup>-Akt and total Akt in ND- or HFD-fed mouse bra...
<p>A) Insulin tolerance test of <i>Ptprt</i><sup>+/+</sup> (n = 8) and <i>Ptprt</i><sup>−/−</sup> (n...