<p>Concentration-distance profiles of internalized ligand-receptor complexes computed for (medium cell density) and s as a function of diffusion coefficient. These profiles are defined inside the cell () and distance is measured in the radial direction from the center of the cell. The values of the diffusion coefficient ) are: a) 0.05; b) 0.1; c) 0.2; d) 0.5; e) 1. Other conditions as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021786#pone-0021786-g003" target="_blank">Fig.3</a>.</p
<p>Spatial distribution of ligand computed at , nM, , , for four cell densities: A) high cell densi...
<p>The <i>D</i> of Alexa488 dextran (10 kDa) was measured at various distances from the cell surface...
Previous methods to determine equilibrium binding constants of proteins interacting with ligands inc...
<p>Top:2D spatial distributions of internalized ligand-receptor complexes and free receptors (LRI an...
<p>Ligand profiles computed as a function of distance at low cell density () for nM. The -values (s...
<p>Concentration-time profiles of ligand computed at medium cell density () for nM. These profiles ...
<p>Ligand profiles computed as a function of distance at high cell density () and nM for s (A) and...
<p>Concentration-time profiles of LRI computed at high (, curves a) and low (, curves b) cell densit...
<p>The LRI response was computed at the center of the cell () and expressed as the area under the co...
<p>Concentration responses of L, RS, LRS, and LRI to step changes in the ligand input rate. Two inpu...
<p>Circles are obtained from the simulation; the lines are guides to the eye. For this data, the sec...
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
Cell surface receptors bind extracellular ligand molecules and transport those ligands into the cell...
<p>(a) Intracellular () and extracellular () ligand concentration in the plane for different times....
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
<p>Spatial distribution of ligand computed at , nM, , , for four cell densities: A) high cell densi...
<p>The <i>D</i> of Alexa488 dextran (10 kDa) was measured at various distances from the cell surface...
Previous methods to determine equilibrium binding constants of proteins interacting with ligands inc...
<p>Top:2D spatial distributions of internalized ligand-receptor complexes and free receptors (LRI an...
<p>Ligand profiles computed as a function of distance at low cell density () for nM. The -values (s...
<p>Concentration-time profiles of ligand computed at medium cell density () for nM. These profiles ...
<p>Ligand profiles computed as a function of distance at high cell density () and nM for s (A) and...
<p>Concentration-time profiles of LRI computed at high (, curves a) and low (, curves b) cell densit...
<p>The LRI response was computed at the center of the cell () and expressed as the area under the co...
<p>Concentration responses of L, RS, LRS, and LRI to step changes in the ligand input rate. Two inpu...
<p>Circles are obtained from the simulation; the lines are guides to the eye. For this data, the sec...
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
Cell surface receptors bind extracellular ligand molecules and transport those ligands into the cell...
<p>(a) Intracellular () and extracellular () ligand concentration in the plane for different times....
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
<p>Spatial distribution of ligand computed at , nM, , , for four cell densities: A) high cell densi...
<p>The <i>D</i> of Alexa488 dextran (10 kDa) was measured at various distances from the cell surface...
Previous methods to determine equilibrium binding constants of proteins interacting with ligands inc...