Spatio-temporal distributions of LRI and RI species.

<p>Top:2D spatial distributions of internalized ligand-receptor complexes and free receptors (LRI and RI species) computed at medium-high cell density () and . The white space inside the larger circle is the extracellular medium. The concentration gradients of LRI and RI are established in opposite directions. Bottom: concentration-time profiles of LRI and RI at close proximity to the cell surface (, curves a) and at the center of the cell (, curves b). Other conditions as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021786#pone-0021786-g003" target="_blank">Fig.3</a>.