Concentration-time profiles of LRS and LRI without recycling of internalized receptors.

<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation ratio : curves (a,a') , curves (b,b') . X = LRS (solid lines), X = LRI (dashed lines). There is no recycling of empty receptors to cell surface (). Panel A: curves obtained using the spatial model. Panel B: curves obtained with the non-spatial model of ref.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021786#pone.0021786-Zi1" target="_blank">[21]</a>. Other conditions for panels A and B as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021786#pone-0021786-g012" target="_blank">Fig.12</a>.