Inducing LTP in area CA1 in APPPS1-21 mice or littermate wild type controls aged 8 months showed robust LTP that lasted for 1 h post-HFS (n = 12 per group).

<p>A 2-way repeated measures ANOVA showed a difference between genotype (p<0.001) over time (p<0.0001), showing that there was a decay of LTP in both groups. Below: Shown are typical field fEPSPs of recordings 5 min before (left) and 1 h after HFS (right).