Reversal of LTP deficit in aged 3×Tg mice by SERMs is GPR30 dependent.

<p>LTP was measured after TBS in the CA1 region of hippocampal sections from 16 month male 3×Tg mice or WT controls. Test compounds (SERMs 100 nM; G15 100 nM) were added 30 min prior to TBS. (<b>A, B</b>) DMA and NO-DMA restored deficits in LTP to WT levels and G15 blocked the actions of DMA. (<b>C</b>) Secondary analysis of theta bursts indicate action both during induction and stabilization of LTP, through a GPR30 dependent mechanism. Data show mean and S.E.M. normalized to baseline (n = 4–9); for end fEPSP: * = p<0.05, ** = p<0.01 compared to wild type transgenic background controls using one-way ANOVA with Dunnett's post hoc test; F_(4,32) = 8.21, p = 0.0001.