Age dependent changes in the LTP of the 3xTg-AD mice and the lipoic acid effect.

<p>LTP was induced at baseline intensity using theta burst stimulation (TBS) consisting of ten trains of five 100 Hz stimulation repeated at 5 Hz. Slope of EPSPs was measured and results normalized to the average value measured during the 10 min baseline period. Recording continued for at least 30 min following TBS and the last 5 min was used to calculate the LTP. Panels A, B, and C correspond to data from young mice, whereas, panels D, E, and F correspond to data from old mice (gray circles/bars – control (nonTg or 3xTg-AD), black circles/bars – fed lipoic acid (nonTg or 3xTg-AD + lipoic acid). A graph showing the first 10 min of baseline followed by the percentage of the baseline response elicited after TBS for 30 min for (A) young nonTg mice, (B) young 3xTg-AD mice, (D) old nonTg mice, (E) old 3xTg-AD mice. Bar graphs showing the measured LTP using % EPSP for the last 5 min of the response to TBS stimulation for (C) young mice and (F) old mice. Total <i>n</i> = 51 slices, <i>n</i> ≥ 5 slices/group and at least 3-4 animals/group. *<i>P</i> ≤ 0.05, **<i>P</i> ≤ 0.01.