LTP induction by a HFS protocol: D1Rs and 5-HT1ARs modulate the potentiation of the excitation in PFC.

<p>(A) LTP responses induced in L5PyNs from 129/Sv mice recorded for 15 min, 30 min, 45 min and 60 min after the HFS protocol. Histograms represent relative changes (compared to control) of conductances, IntgT (black bars), IntgE (red bars) and IntgI (blue bars). Conductances are determined with a low frequency of stimulation (0.05 Hz) in resting conditions or after the HFS protocol. (B) LTP responses induced in L5PyNs from 5-HT_1AR-KO mice recorded for 15 min, 30 min, 45 min and 60 min after the HFS protocol. (C) LTP responses induced in L5PyNs from 129/Sv mice recorded for 15 min, 30 min, 45 min and 60 min after the HFS protocol in the presence of the D1R antagonist SCH 23390 (10μM). Histograms represent relative conductance changes (compared to the resting condition following 15 min pre-incubation of the antagonist <i>i</i>.<i>e</i>. 100%), IntgT (black bars), IntgE (red bars) and IntgI (blue bars). (D) LTP responses induced in L5PyNs from 5-HT_1AR-KO mice in the presence of SCH 23390 (10μM). (E) LTP responses induced in L5PyNs from 129/Sv in the presence of the D1R agonist SKF 81297 (10μM). Histograms represent relative conductance changes (compared to the resting condition following 15 min pre-incubation of the agonist <i>i</i>.<i>e</i>. 100%), IntgT (black bars), IntgE (red bars) and IntgI (blue bars). (F) LTP responses induced in L5PyNs from 5-HT_1AR-KO mice in the presence of SKF 81297 (10μM). Error bars represent S.E.M. (* p < 0.05, ** p < 0.01;*** p<0.001).