GC species in the liver and lung.

<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9H/9H and 9H;C*), V394L (4L/4L and 4L;C*), D409V (9V/9V, 9V/null, and 9V;C*) and N370S (0S/0S and 0S;C*). The panels are grouped to reflect the various mutations to facilitate comparison of the GC levels. The ordinates differ to facilitate visualizing the differing levels of GC. Age-matched WT tissues were controls for each analysis. 4L;C* lung at 6 wks was compared to WT at 9 wks. Each GC species level in the mutant was analyzed relative to age-matched WT using Student’s t-test. *, p<0.05, **, p<0.01, ***, p<0.0001, ****, p<0.00001. The results and error bars are the mean+S.E. (n = 3–4 mice).