GlcCer species in visceral tissues of 9V/null/GCStg mice.

<p>(A) Tissue GlcCer species in the lungs, livers, spleens and brains from 9-wk of WT, WT+GCStg, 9V/null and 9V/null+GCStg mice were quantitated by LC/MS analysis. The concentration of each GlcCer species was plotted as pmol/mg tissue (Y-axis) in bar graph vs. GlcCer species in X-axis. *, <i>p</i><0.05 and **, <i>p</i><0.001 were from one-way ANOVA analysis by comparison of 9V/null and 9V/null+GCStg. (B) Tissue GlcCer species patterns. Each GlcCer species was presented as the percentage of total amount of GlcCer species (Y-axis) in each tissue as indicated. The ratios of each GlcCer species in WT and 9V/null tissues were similar to that in their GCStg counterpart tissues. 9V/null lung had increased GlcCer 24−0 species. Experiments were done in triplicate and repeated at least twice. Results with error bars are mean ±S.E.