<p>Total GC levels in liver, lung, and spleen from 9V/null (red), 9H/9H (violet), 9V/9V (green), and 4L/4L (orange) mice. In 9V/null the GC levels progressively accumulated from 4 to 52 wks and at greater rates in the lung than in liver and spleen. 9H/9H, 9V/9V, and 4L/4L mice had GC increases slightly above WT (black) levels. Data are mean±S.E. (n = 3–4 mice).</p
<p>(A) Cortex GC and GS levels in IFG treated 4L;C* did not show significant reduction relative to t...
The concentration of β‐glucosidase‐stimulating proteins (called cohydrolase here) was measured in mo...
<p>(A) H&E staining of spleen sections of <i>Npc1</i><sup>+/+</sup> and <i>Npc1</i><sup><i>nih/nih</...
<p>(A) Spleen GC level in 4L;C* mice was not different from that in the WT. GS level was accumulated...
<p>(A) GlcCer concentration in visceral tissues. The lungs, livers and spleens from 9-, 18-, 28- and...
<p>(A) The mean proportion of each GC species relative to total GC (6 GC species) in age-matched <i>...
<p>Each graph depicts glucosylsphingosine levels in four tissues from mice having the same <i>Gba 1<...
<p>The fold changes of GC species and glucosylsphingosine levels in individual mutant mice were age-...
<p>GC species in the spleen (9H/9H, 9H;C*, 4L/4L, 4L;C*, 9V/9V, and 9V/null), whole brain (9H;C*, 4L...
<p>(A) Tissue GlcCer species in the lungs, livers, spleens and brains from 9-wk of WT, WT+GCStg, 9V/...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
Gaucher disease results from GBA1 mutations that lead to defective acid b-glucosidase (GCase) mediat...
Gaucher disease results from GBA1 mutations that lead to defective acid β-glucosidase (GCase) mediat...
Glucosylceramide and glucosylsphingosine are the two major storage products in Gaucher disease (GD),...
Gaucher disease is a lysosomal storage disease caused by defective activity of acid β-glucosidase (G...
<p>(A) Cortex GC and GS levels in IFG treated 4L;C* did not show significant reduction relative to t...
The concentration of β‐glucosidase‐stimulating proteins (called cohydrolase here) was measured in mo...
<p>(A) H&E staining of spleen sections of <i>Npc1</i><sup>+/+</sup> and <i>Npc1</i><sup><i>nih/nih</...
<p>(A) Spleen GC level in 4L;C* mice was not different from that in the WT. GS level was accumulated...
<p>(A) GlcCer concentration in visceral tissues. The lungs, livers and spleens from 9-, 18-, 28- and...
<p>(A) The mean proportion of each GC species relative to total GC (6 GC species) in age-matched <i>...
<p>Each graph depicts glucosylsphingosine levels in four tissues from mice having the same <i>Gba 1<...
<p>The fold changes of GC species and glucosylsphingosine levels in individual mutant mice were age-...
<p>GC species in the spleen (9H/9H, 9H;C*, 4L/4L, 4L;C*, 9V/9V, and 9V/null), whole brain (9H;C*, 4L...
<p>(A) Tissue GlcCer species in the lungs, livers, spleens and brains from 9-wk of WT, WT+GCStg, 9V/...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
Gaucher disease results from GBA1 mutations that lead to defective acid b-glucosidase (GCase) mediat...
Gaucher disease results from GBA1 mutations that lead to defective acid β-glucosidase (GCase) mediat...
Glucosylceramide and glucosylsphingosine are the two major storage products in Gaucher disease (GD),...
Gaucher disease is a lysosomal storage disease caused by defective activity of acid β-glucosidase (G...
<p>(A) Cortex GC and GS levels in IFG treated 4L;C* did not show significant reduction relative to t...
The concentration of β‐glucosidase‐stimulating proteins (called cohydrolase here) was measured in mo...
<p>(A) H&E staining of spleen sections of <i>Npc1</i><sup>+/+</sup> and <i>Npc1</i><sup><i>nih/nih</...